Tuesday, March 26, 2013

Hypogonadism - Take Home Messages

Hypogonadism - Take Home Messages by Ernani Luis Rhoden Federal University of Medical Sciences of Porto Alegre, Brazil. The PDF contains Lectures and debates, Poster presentations, Basic and clinical science, Podium presentations, Basic and clinical science. “Testosterone deficiency is clinical and not a biochemical condition”. T improves response rates in PDE5i failures, Hypogonadal men who do no respond to treatment of ED with PDE5inhibitors may be rescued with androgen suplemmentation. Testosterone replacement therapy should be used to treat men with Peyronie’s disease ? There are limited data regarding the relationship of T levels and Peyronie’s Disease. Basic Science Kataoka T et al., Japan in an experimental study using an animal model of Metabolic Syndrome: Reduced levels of testosterone, Increased oxidative stress in cavernous tissue, Increased smooth muscle injury, Increased endothelial dysfunction, TRT in those animals: Supressed inflamatory response, Protected smooth muscle injury,Improved endothelial dyfunction. Shin et al., South Korea demonstrated, in a placebo control study, that hypogonadal men demonstrated beneficial effects of TRT on cognitive evaluation as well as on depression scores. Saad F et al., Germany, in a large number of ypogonadal men (n:255) demonstrated continuosly beneficial effects of TRT (up to 60 months) on erectile function, urinary symptoms, and inflammatory response. Zitzmannn et al., Germany, reported their data on 334 hypogonadal men under TRT up to 15 years , with significant and continuosly improvement in lipids, BMI and waist circunferences. Graph of International Index of Erectile Function (IIEF - -EF) EF) in 255 in 255 Middle Middle - - Aged to Elderly Men Treated with TU up to 60 mo Aged to Elderly Men Treated with TU up to 60 mo. Graph of International Prostate Symptom Score (IPSS) in 255 Middle in 255 Middle - -Aged to Elderly Men Treated with TU up to 60 mo Aged to Elderly Men Treated with TU up to 60 mo. Graph of International Prostate Symptom Score (IPSS) in 255 Middle in 255 Middle - - Aged to Elderly Men Treated with TU up to 60 mo Aged to Elderly Men Treated with TU up to 60 mo. C--Reactive Protein (CRP, mg/dl)Reactive Protein (CRP, mg/dl) in 255 Middle in 255 Middle - -Aged Aged to Elderly Men Treated with TU up to 60 mo to Elderly Men Treated with TU up to 60 mo. Body Weight (kg) in 255 Hypogonadal Men (mean age: 60.6years) Treated with Testosterone Undecanoate Injections years) Treated with Testosterone Undecanoate Injections for up to 60 months.

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