Wednesday, February 13, 2013

The 'rule of 5' and its implementation

The 'rule of 5' and its implementation - poor absorption or permeation are more likely when: There are more than 5 H-bond donors (expressed as the sum of OHs and NHs); The MWT is over 500; The Log P is over 5 (or MLogP is over 4.15); There are more than 10 H-bond acceptors (ex pressed as the sum of Ns and Os.

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