weSRCH.com an on-line symposium for professionals; members can read and post technical papers, upload free press releases, submit press releases in High Tech, Med Tech, and Green Tech. It fosters innovation and professional development through publication.
Wednesday, February 13, 2013
The 'rule of 5' and its implementation
The 'rule of 5' and its implementation - poor absorption or permeation are more likely when: There are more than 5 H-bond donors (expressed as the sum of OHs and NHs); The MWT is over 500; The Log P is over 5 (or MLogP is over 4.15); There are more than 10 H-bond acceptors (ex pressed as the sum of Ns and Os.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment